Did a rare and unique symbiotic relationship result in a state of suspended maturation, a perpetual state of juvenility and the emergence and expansion of an increasingly symmetric juvenile brain that brought with it a raft of unusual traits?
Monday, 15 January 2018
Sunday, 14 January 2018
“Our data further endorse current recommendations on increasing whole fruits, but not fruit juice, as a measure for diabetes prevention,” said lead author Isao Muraki, research fellow in the Department of Nutrition at HSPH. “And our novel findings may help refine this recommendation to facilitate diabetes prevention.”
Saturday, 13 January 2018
Mechanism of Nerve Growth Factor GDNF Elucidates Ibogaine’s Persistence and Immune Modulatory Effects
This slide presentation/lecture explores ibogaine’s persistent “resprouting” of dopaminergic dendrites and receptors via the nerve growth factor Glia-Derived Neurotrophic Factor (GDNF) as a marker for a broader REM-mimetic neuro-plasticity with outcomes ranging from behavioral to immune-system benefits.
Ibogaine shares robust receptor effects with both Salvia Divinorum (kappa opiate agonism, down-regulating tolerance via beta-arrestin) and with ketamine (n-Methyl-d-Aspartate antagonism, curbing narcotic withdrawal and super-sensitization to stimulants). However, neither of these account for ibogaine’s signature long-lasting effect against cocaine/alcohol (Bruno Rasmussen Chaves, 2014) or opiate abuse (Thomas Kingsley Brown, 2017).
In a series of papers (2005, 6, 10) Dorit Ron et al established that ibogaine unexpectedly expresses the nerve growth factor (GDNF), re-sprouting chronically desensitized dopamine receptors, replacing the neural deficit experienced as craving. Not only that, the 10-fold GDNF spike engendered by ibogaine back-signals to cell nuclei to make more GDNF, setting up a persistent, benign auto-regulatory loop that accounts for ibogaine’s persistent effect. This is confirmed by the recent discovery that as little as 4 mgs of ibogaine twice a day for 28 days significantly reverses Parkinson’s degeneration (case studies, unpublished), since one typical effect of end-stage methamphetamine abuse on dopamine function is Parkinsonianism.
Interestingly, the thesis that ibogaine is a true oneiric which one experiences as “a dream body in a dream landscape” (Alper, Lotsof 2009) as elaborated in Carl Anderson’s prescient paper (MAPS, 1998) on ibogaine and fetal REM is buttressed by the fact that knock-out mice without a GDNF gene have no adrenals because they are born without kidneys. This raises intriguing issues not only of REM as orchestrator of fetal/neonatal growth, but the extreme usefulness of a true REM-mimetic in modulating the immune systems of adults seen in ibogaine amelioration of auto-immune disorders such as MS and Crohn’s disease (case studies), and some complications of AIDS.
Saturday, 4 November 2017
The concept of an original Paradise is a mythic theme in world folklore. Nearly all ancient agrarian peoples entertained visions of a Golden Age—a primordial era when human beings believed the cosmos was alive and conscious, when they lived in harmony with nature and respected the elements of nature as living parts of a living whole.
Sunday, 29 October 2017
"You all have wonderful genes. Your genes are a gift." You have a genetic expression that is reacting to a poor choice. Gluten is the family of proteins found in the seeds of grasses.There are many types of gluten. Gluten is a neurotoxin.
Peter Osborne is an incredible health educator. Here are two of his interviews.
Thursday, 26 October 2017
Forbidden Dimensions by C G Browne
"C.G.Browne's book is one of the best if you are looking for a gritty and alternative account of how life has been in prehistory and how it still is today, otherworld and all! To be honest, there's nothing else to talk about in today's difficult world, so my own new book will inevitably follow a similar theme. I think it helps if we all get real and think real."
Patrick Jasper Lee